Nesiritide. The Rise and Fall of Scios

Book Cover

NONFICTION SCIENCE AND MEDICINE

1980s & '90s

Roger M. Mills MD

Logline

Nesiritide is the story of a biotech drug: where it came from, how it struggled through the FDA approval process, and how an unfounded safety scare in the press killed it.

Genre

,Nonfiction science and medicine

Target Audiences

Age: 35-54

Target Gender: Universal

Setting

San Franciso Bay area (the company) and Washington DC (the FDA)

Based on a True Story

Yes

Publishing Details

Status: Yes: self-published

Year Published: 2016

Starting Description

In 1975, Eddy Buczynski developed acute heart failure. Eddy took care of the office building where I worked. I had nothing to help him except Lasix, a diuretic. 20 years later, I had a chance to develop a new drug, nesiritide. I was more than ready.

Ending Description

Nesiritide went through 2 FDA reviews. After approval, it rapidly succeeded in the market. But the company, Scios, didn’t follow through on FDA-recommended studies. Then safety questions hit the press. Glory days turned to disaster. Scios folded, and so did drug development for acute heart failure.

Group Specific

Information not completed

Hard Copy Available

No

ISBN

Information not completed

Mature Audience Themes

Information not completed

Plot - Other Elements

Meaningful Message, Philosophical Questions,Power of the press, even when no correct.

Plot - Premise

,Rags to riches to rags. "Greek tragedy" failure to listen to authority.

Main Character Details

Name: Me. This is a true story, told in the first person as I saw it.

Age: 50

Gender: Male

Role: Protagonist

Key Traits: Educated, Strong Moral Code, Aspiring

Additional Character Details

Name: Dick Brewer, the biotech entrepreneur who led Scios thru the drug development process.

Age: 50

Gender: Male

Role: Protagonist

Key Traits: Aggressive, Confident, Engaging, Leader, Visionary

Additional Character Details

Name: Stephanie Saul

Age: 38

Gender: Female

Role: Antagonist

Key Traits: Complex, Power-hungry

Additional Character Details

Name: The FDA, often represented by Ray Lipicky.

Age: 66

Gender: Male

Role: Logical

Key Traits: Confident, Decisive, Educated, Patriotic, Strong Moral Code

Logline

Nesiritide is the story of a biotech drug: where it came from, how it struggled through the FDA approval process, and how an unfounded safety scare in the press killed it.

Short Summary

In 1975, Eddy Buczynski developed acute heart failure. Eddy took care of the office building where I worked. I had nothing to help him except Lasix, a diuretic. 20 years later, I had a chance to develop a new drug, nesiritide. I was more than ready.


Nesiritide went through 2 FDA reviews. After approval, it rapidly succeeded in the market. But the company, Scios, didn’t follow through on FDA-recommended studies. Then safety questions hit the press. Glory days turned to disaster. Scios folded, and so did drug development for acute heart failure.

Development Pitch

About The Author

Core Theme

,Rags to riches to rags. "Greek tragedy" failure to listen to authority.

Characters

Main Character

Name: Me. This is a true story, told in the first person as I saw it.

Age: 50

Gender: Male

Role: Protagonist

Key Traits: Educated, Strong Moral Code, Aspiring

Character 1

Name: Dick Brewer, the biotech entrepreneur who led Scios thru the drug development process.

Age: 50

Gender: Male

Role: Protagonist

Key Traits: Aggressive, Confident, Engaging, Leader, Visionary

Character 2

Name: Stephanie Saul

Age: 38

Gender: Female

Role: Antagonist

Key Traits: Complex, Power-hungry

Character 3

Name: The FDA, often represented by Ray Lipicky.

Age: 66

Gender: Male

Role: Logical

Key Traits: Confident, Decisive, Educated, Patriotic, Strong Moral Code

Supplemental Materials

Information not completed